The district of the Alto Guadalquivir is located in the south-east part of the province, around the river Guadalquivir bordering to the north with La Loma y Las Villas and to the west with Sierra Magina. A good part of the district belongs to the Cazorla, Segura Las Villas Natural Park.

Municipal Centres: 

Cazorla | Chilluevar | Hinojares | Huesa | La Iruela | Peal de Becerro | Pozo Alcon | Quesada | Santo Tome